Urban Nairobi slums face significant health challenges, including tuberculosis (TB). Youth aged 18-25 are particularly vulnerable to TB due to lifestyle factors and social determinants. A mixed-methods approach was employed, including surveys (n=300) and qualitative interviews (n=50). Data were analysed using thematic analysis and descriptive statistics. Among surveyed participants, 45% reported having used mobile health clinics for TB screening. Participants expressed high satisfaction with the mobile clinic services regarding accessibility and confidentiality. Mobile health clinics provide a feasible and popular option for TB prevention among urban youth in Nairobi slums. Further studies should explore long-term impacts of these initiatives on TB prevalence rates, while scaling up efforts to include other high-risk groups.