The proximate composition of the leaves of Landolphia oweriences, a plant belonging to the Apocynaceae family and commonly known as the white rubber vine, was thoroughly investigated to determine its nutritional profile. Proximate analysis was conducted using the AOAC Method (2005), revealing several key components that highlight its potential as a food source. The results indicated that the leaves contained a moisture content of 8.09 ± 0.21%, which is typical for plant leaves and indicates moderate hydration. In terms of protein content, the leaves were found to contain 15.86 ± 1.46%, suggesting a good source of plant-based protein, which is essential for various physiological functions. The ash content was 4.74 ± 0.14%, which reflects the mineral content of the leaves, important for micronutrient intake.The fat content was measured at 1.07 ± 0.42%, indicating a relatively low fat level, while the crude fiber content was significantly higher at 32.51 ± 1.15%. This high fiber content contributes to digestive health and can aid in managing cholesterol levels. Additionally, the total carbohydrate content (or nitrogen-free extract) was 37.74 ± 2.01%, with soluble carbohydrates accounting for 11.59 ± 0.69%. These figures suggest that the leaves of Landolphia oweriences offer a good balance of macronutrients, making them suitable for human consumption, particularly in regions where other food sources may be limited.