Causes of fish diseases is by viruses, bacteria, parasites, and fungi not only arbitrate aquaculture production but also present significant risks to human health. This comprehensive review explores the epidemiology, transmission, clinical effects, and mitigation strategies related to fish-borne diseases impacting humans through foodborne pathways and occupational exposure. It synthesizes current evidence to inform stakeholders about emerging threats and control measures, emphasizing the need for integrated approaches in surveillance, public health policy, and aquaculture management. Fish borne diseases can have a significant impact on human health, especially when eating spoiled or infected fish. Understanding these risks is essential to preventing foodborne illness and handling and eating fish safely.