This paper explains how an open-source PYTHON- SPYDER tool used to develop the Sine PWM in PYTHON environment. This open source tool is a Scientific PYTHON Development Environment, includes many number of key features to create a SPWM for a two level inverter system. Along with the regular general-purpose array-processing package - numpy and object- oriented API for GUI systems - matplotlib another supporting package which works with the numpy is - scipy are used for the generation of the SPWM for a two level inverter. The results are compared with the MATLAB/Simulink results. The PYTHON-SPYDER offers significant advantages over other approaches. It provides easy and fast simulation time and less complex coding than the other simulation tool packages.