Background: Disorganized Attachment (Type D) is conventionally treated as a unitary category in both clinical assessment and intervention design. However, Main and Cassidy (1988) identified distinct controlling subtypes—Controlling-Punitive (CP) and Controlling-Caregiving (CC)—with divergent behavioral, psychopathological, and developmental trajectories.1,2 Despite this empirical differentiation, no prior work has mapped these subtypes onto the columnar architecture of the midbrain Periaqueductal Gray (PAG) or specified the neurochemical pathways that maintain their distinct regulatory strategies. Objective: This paper proposes the Dual-Mode Hypothesis: that the CP–CC bifurcation in disorganized attachment reflects the chronic stabilization of opposing PAG defense columns—dorsolateral PAG (dlPAG) for CP and ventrolateral PAG (vlPAG) for CC—maintained by divergent endogenous opioid systems. We further introduce the Opioid-Differentiation Hypothesis, positing that CP regulation operates via a catecholamine–dynorphin/κ-opioid receptor (KOR) axis, while CC regulation operates via an enkephalin–β-endorphin/μ-opioid receptor (MOR) axis.3,4,5 Methods: The model integrates six convergent evidence streams: (1) developmental psychology of disorganized attachment subtypes (Main & Cassidy, 1988; Moss et al., 2004; Lyons-Ruth, 2003); (2) PAG columnar neuroscience and reciprocal inhibition (Bandler & Shipley, 1994; Keay & Bandler, 2001); (3) endogenous opioid pharmacology in defense regulation; (4) Polyvagal Theory and the defense cascade (Porges, 2011); (5) Non-Suicidal Self-Injury (NSSI) research; and (6) elite performance and Adverse Childhood Experience (ACE) literature. Results: The Dual-Mode Hypothesis generates three testable predictions: (a) the Extreme Sport Hypothesis—that CP subtypes are overrepresented in high-arousal, high-risk activities serving as “socially sanctioned self-harm” via dlPAG-mediated Shame Lock override (the Punitive Reset); (b) the Dual-Mode Self-Harm Hypothesis—that CP and CC subtypes exhibit qualitatively distinct NSSI patterns (externalized/public vs. internalized/private) targeting different PAG columns; and (c) the Caregiving-Freeze Loop—that CC subtypes exhibit a unique “active-passive” hybrid state combining vlPAG metabolic shutdown with social engagement behavior, incurring disproportionate neuroimmunological cost.6,7,8 Conclusions: The Dual-Mode Hypothesis extends the ABM three-profile system to a five-profile taxonomy (Architect, Radar, Special Forces–Protest, Special Forces–Absorber, Special Forces–Undifferentiated), providing the neurobiological substrate for the 15-configuration Relational Collision Matrix introduced in Paper 9. It generates falsifiable predictions assessable via MCDC scales, sensation seeking inventories, and NSSI screening tools.