Salivary biomarkers have gained significant attention as non-invasive diagnostic tools for the early detection of systemic diseases such as diabetes, cancer, and immune system disorders. Saliva contains a wide range of biological molecules, including proteins, enzymes, hormones, antibodies, and nucleic acids, which reflect both oral and systemic health status. Recent studies demonstrate that changes in salivary biomarker profiles can indicate metabolic dysregulation, inflammatory processes, and malignant transformations at early stages of disease development [1, 2]. The use of saliva-based diagnostics offers advantages such as easy sample collection, cost-effectiveness, and patient comfort. Advances in proteomics, genomics, and biosensor technologies further enhance the sensitivity and specificity of salivary biomarker detection, supporting their potential role in preventive and personalized medicine [3,4].