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Article . 2026
License: CC BY
Data sources: Datacite
ZENODO
Article . 2026
License: CC BY
Data sources: Datacite
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Long-Term Cognitive and Functional Outcomes in Parkinson's Disease: Current Evidence and Emerging Insights

Authors: Filza Haq, Nawaz;

Long-Term Cognitive and Functional Outcomes in Parkinson's Disease: Current Evidence and Emerging Insights

Abstract

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor symptoms such as bradykinesia,resting tremor, rigidity, and postural instability as well as a wide spectrum of non-motor manifestations including cognitiveimpairment, mood disturbances, sleep dysfunction and autonomic abnormalities. One of the most common concomitant diseases in PD is dementia which can be seen as a gradual cognitive decline especially in executive function, attention and visuospatial skills. Functional decline and its progression in patients are variable depending on various factors such as the age of disease onset, motor type, comorbidities and neurobiological mechanisms such as alpha-synuclein aggregation and the breakdown of cholinergic activity. Emerging neuroimaging and biomarker technologies are being examined to ascertain their role in predicting future patients' responses and directing personalized medical treatments. Apart from the mental activities and medical treatments, physical exercises, occupational therapy and cognitive rehabilitation all help in sustaining patients' independence and mental well-being. Additionally, caregivers are unparalleled in achieving better results for patients. Future research integrating precision medicine, digital health technologies and disease-modifying therapies promises to improve longterm cognitive and functional trajectories in PD.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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