Mutrashmari is one of the most common disorders of Mutravaha Srotas, characterized by the formation of urinary stones and known for its recurrent nature, thereby being included under Ashtamahagada. In contemporary medicine, it is correlated with urolithiasis based on similar clinical features. Factors such as dietary habits, water intake, climate, and geographical conditions play a significant role in its pathogenesis. Ayurveda emphasizes both the prevention of stone formation and the elimination of existing calculi through Shodhana, Shamana, and Shastra Karma, with Trividha Basti Karma considered the treatment of choice, especially in the early stages. The present study focuses on the therapeutic efficacy of Matra Basti with Kulatthadi Ghrita and Varunadi Taila, along with Shamana Aushadhi such as Swadamshtradi Kwatha, as described in Chakradatta, due to their Ashmari Bhedana, Ashmari Patana, and Mutrala properties in the management of Mutrashmari. Objective 1. To evaluate the combined efficacy of varunadi taila matrabasti with swadamshtradi kwatha in the management of Mutrashmari vis a vis Urolithiasis in group A 2. To evaluate the combined efficacy of kulattadhya ghrita matrabasti with swadamshtradi kwatha in the management of Mutrashmari vis a vis Urolithiasis in group B 3. To Compare the Efficacy Between Group A And Group B. Methods: A comparative clinical trial was conducted on 40 patients, who were equally divided into two groups. Group A was administered Varunadi Taila Matra Basti (70 ml) for 8 days, while Group B received Kulatthadhya Ghrita Matra Basti (70 ml) for the same duration. From the 9th day onwards, both groups were given Swadamshtradi Kashaya orally in a divided dose of 24 ml twice daily before food with honey as Anupana for 30 days. Assessments were carried out on the 0th, 9th, and 39th days using subjective and objective parameters, including ultrasonography. Statistical analysis was performed using SPSS software with appropriate tests. Results: Group A showed an overall improvement of 74.65%, while Group B demonstrated a slightly higher overall improvement of 76.70% from Pretest to Post-test. Both groups showed substantial progress, with Group B showing a marginally greater overall effect. Conclusion: Kulattadhya Ghrita proved more effective than Varunadi Taila in relieving symptoms of Mootrashmari.