Background: Androgenetic alopecia (AGA) is a progressive, androgen-mediated disorder characterized by follicular miniaturization. Platelet-rich plasma (PRP), an autologous biologic therapy enriched with growth factors, has emerged as a regenerative treatment modality in dermatology. Objective: To critically evaluate current scientific evidence regarding the efficacy, mechanisms, safety, and clinical application of PRP in androgenetic alopecia. Methods: A structured literature review was conducted using electronic databases including PubMed, Scopus, and Google Scholar. Randomized controlled trials (RCTs), prospective studies, and systematic reviews published between 2013 and 2025 were analyzed. Results: Most controlled studies demonstrate statistically significant improvement in hair density, hair shaft thickness, and global photographic scores following PRP therapy. However, variability in preparation protocols, platelet concentration, leukocyte content, activation methods, and outcome assessment limits inter-study comparability. PRP demonstrates a favorable safety profile with minimal adverse events. Conclusion: PRP represents a promising regenerative therapy for AGA, particularly in early to moderate disease. Standardization of preparation techniques and long-term, large-scale randomized trials are essential to establish definitive treatment guidelines.