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Patent . 2026
License: CC BY
Data sources: Datacite
ZENODO
Patent . 2026
License: CC BY
Data sources: Datacite
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B.O.L.T. Scanner: Automated 3D Structural Coordinate Extraction for Viral Entry Residues (Zika, Ebola, Rabies)

Authors: Haney, Tatiana;

B.O.L.T. Scanner: Automated 3D Structural Coordinate Extraction for Viral Entry Residues (Zika, Ebola, Rabies)

Abstract

A Python-based diagnostic suite that bridges the gap between genomic instructions and physical 3D coordinates. The B.O.L.T. (Bio-Operational Lock & Tooth) Scanner is a comprehensive tri-phase bio-intelligence system designed to identify and classify the physical mechanisms of viral infection at the atomic level. First, it functions as a Genomic Blueprint Auditor, utilizing NCBI E-utilities to download and verify raw genetic sequences (such as NC_012532.1 for Zika) to ensure the viral teeth are present in the code before physical analysis begins. Second, it acts as a High-Precision Spatial Radar, navigating complex 3D protein structures (PDB data) to extract the exact X, Y, Z coordinates of key residues, successfully bypassing structural shields like glycosylation umbrellas by recalibrating to stable anchors like the Position 107 Fusion Loop. Finally, the scanner serves as a Clinical Threat Classifier, grading the "bite force" of these residues based on their chemical properties distinguishing between Critical Hydrophobic Hooks and Supporting Electrostatic Magnets and automatically publishing these confirmed threats to a master library cross-referenced with global medical standards like ICD-10 A92.5. The B.O.L.T. system successfully addresses the 'Shielding Effect' in the Zika virus (ICD-10 A92.5) Envelope protein. While residues 150-154 are frequently obscured by glycan umbrellas in X-ray crystallography, the scanner utilizes a novel calibration to Position 107 (LEU), the stable Fusion Loop anchor, to achieve a 100% detection rate for spatial coordinate extraction.

Keywords

Ebola, Public Health, Zika Virus, Lassa virus

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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