This article examines the scientific and methodological foundations for organizing educational–practical activity clusters within the higher education system. The study analyzes issues related to the systematic organization of cooperation among higher education institutions, industrial enterprises, and research organizations. Based on the cluster approach, mechanisms for integrating the educational process with practical activities, forming professional competencies, and improving the quality of specialist training are substantiated. In addition, the role of methodological support, management processes, and innovative pedagogical technologies in organizing educational–practical activity clusters is revealed. The research findings have scientific and practical significance for introducing the cluster approach in higher education and increasing educational effectiveness.