INTRODUCTION: The ethics of human subjects research is complex, evolving, and inadequately addressed through current didactic instruction. Responsible Conduct of Research (RCR) courses, required by US federal funders, can provide additional training. In this report, we discuss the creation of a robust, case-based RCR session on research ethics that was integrated with other institutional services. METHODS: We developed an interactive, case-based ethics session for Northwestern University's CTSA's RCR course. Cases are derived from common ethical challenges encountered in clinical and translational research. The session is facilitated by the co-directors of the Clinical Ethics Research Consultation (CREC) Service and employs small and large group discussion as well as facilitation in conducting ethical analysis. Learner engagement and perceived relevance will be assessed through post-session evaluations and qualitative feedback. RESULTS: Our session will be delivered in January 2026. We expect high levels of engagement and perceived applicability to RCR participants' current research. We anticipate that learners will feel that the session improved their ability to identify ethical issues, appreciate multiple stakeholder perspectives, and understand when further expertise and support by a CREC is needed to apply regulatory and ethical frameworks to ambiguous situations. DISCUSSION: Addressing real-world ethical issues within RCR education can help move investigators from rule-based knowledge towards applied ethical reasoning. This approach fosters critical thinking and reflexivity essential for high-quality clinical and translational research. Such sessions, along with support from a CREC and other institutional bodies can foster an ethical culture and support the CTSA mission to advance responsible, equitable, and impactful research.