Entrepreneurship and innovation are widely recognized as fundamental drivers of economic growth, competitiveness, and technological advancement. Start-ups, in particular, play a critical role in introducing novel products, services, and business models that disrupt traditional markets and create new value. However, the suc-cess of start-ups depends not only on entrepreneurial intent but also on the effec-tive management of innovation under conditions of uncertainty, limited resources, and rapidly changing market environments. This paper examines the interrelation-ship between entrepreneurship, start-ups, and innovation management, emphasiz-ing how strategic entrepreneurial orientation and structured innovation processes contribute to sustainable competitive advantage. Drawing on established entrepreneurship and innovation theories, this study syn-thesizes existing literature to analyze key dimensions such as opportunity recogni-tion, entrepreneurial orientation, lean innovation practices, and the role of entre-preneurial ecosystems. The paper highlights how start-ups can manage innovation through agile methodologies, customer-centric development, and open innovation networks to improve adaptability and market responsiveness. Furthermore, it pro-poses an integrated conceptual framework linking entrepreneurial orientation, in-novation management practices, ecosystem support, and performance outcomes. The findings suggest that start-ups with strong entrepreneurial orientation and sys-tematic innovation management capabilities are better positioned to achieve scala-bility, resilience, and long-term growth. The study contributes to the entrepreneur-ship and innovation literature by offering a holistic perspective that bridges strate-gic intent and operational execution. Practical implications are provided for entre-preneurs, investors, and policymakers seeking to foster innovation-driven entre-preneurial ecosystems. The paper concludes by identifying future research direc-tions to empirically validate the proposed framework across industries and region-al contexts.