METABOLIK SINDROM SHAROITIDA A'ZO VA TО'QIMALARNING TIZIMLI SHIKASTLANISHINING PATOGENETIK MEXANIZMLARI
METABOLIK SINDROM SHAROITIDA A'ZO VA TО'QIMALARNING TIZIMLI SHIKASTLANISHINING PATOGENETIK MEXANIZMLARI
Ushbu maqolada metabolik sindromning rivojlanishida a’zo va tо‘qimalarning tizimli shikastlanish mexanizmlari tahlil qilingan. Metabolik sindrom – bu insulin rezistentlik, abdominal semizlik, dislipidemiya va arterial gipertenziya kabi о‘zaro bog‘liq holatlar majmuasidan iborat murakkab patologik jarayon bо‘lib, u organizmning deyarli barcha tizimlariga salbiy ta’sir kо‘rsatadi. Tadqiqotda yurak-qon tomir, jigar, buyrak, miya va endokrin tizimlarda kuzatiladigan strukturaviy hamda funksional о‘zgarishlarning asosiy patofiziologik mexanizmlari yoritilgan. Shuningdek, oksidlovchi stress, yallig‘lanish sitokinlari, adipokinlar va mikroRNAlarning о‘zaro ta’siri tizimli shikastlanishning asosiy sabablari sifatida tahlil qilingan. Maqola metabolik sindromning kо‘p yо‘nalishli patogenezini anglash orqali uning oldini olish va davolash strategiyalarini ilmiy asoslashga xizmat qiladi.
metabolik sindrom, insulin rezistentlik, oksidlovchi stress, yallig'lanish, adipokinlar, a'zo shikastlanishi, tizimli disfunksiya
metabolik sindrom, insulin rezistentlik, oksidlovchi stress, yallig'lanish, adipokinlar, a'zo shikastlanishi, tizimli disfunksiya
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