Abstract. The growth of the economy is one of the key goals of macroeconomic policy, especially in the context ofdeveloping and transitional economies that aim at the achievement of sustainable development and better livingstandards. Gross Domestic Product (GDP) is an important indicator used to measure the performance of an economyby providing an analysis of the level of investment activity, sector structure, and macroeconomic stability. Uzbekistanhas experienced significant structural and institutional changes over the last several years to liberalize the economyand empower market mechanisms; therefore, the analysis of its key economic indicators and GDP growth is not onlytimely but also relevant. Although an extensive literature on the subject is growing, a significant gap in knowledge abouta multifaceted econometric evaluation of the aggregate impact of several macroeconomic variables on GDP growth inUzbekistan in the medium and long term remains.In order to fill this gap, the research methodology involves the use of a quantitative econometric design based on annualmacroeconomic variables for 2010–2025. The dependent variable is GDP growth, and the regression model used is amulti-factor regression applying the ordinary least squares method. The explanatory variables are investment in fixedcapital, industrial production, development of the services sector, and inflation. As the empirical data show, investmentactivity and industrial production have a statistically significant positive effect on GDP growth, which proves the key roleof capital accumulation and real sector growth in the development of the Uzbekistan economy. The services industrymakes a positive contribution but to a lower degree, whereas inflation shows a negative correlation with economic growth.The implications of the findings are that, to ensure long-term economic growth in Uzbekistan, the country will have tomaintain investment-based development, diversify its industry, modernize its services sector, and ensure macroeconomicstability. The study offers policy-makers evidence-based information on the topic and contributes to the broader body ofresearch reflecting economic development in transition economies.