Objective: To systematically review and synthesize recent evidence (2020–2025) on the role of clinical pharmacists in type 2 diabetes management, focusing on clinical outcomes, patient education, adherence, and cost-effectiveness. Methods: Literature from PubMed, Scopus, and other databases (2020–2025) was reviewed, including randomized controlled trials, cohort studies, and systematic reviews examining pharmacist interventions in diabetes care. Results: Pharmacist-led interventions achieved significant reductions in HbA₁c (0.52 to 3.59%), improved patient adherence, and enhanced cost-effectiveness. Structured clinics such as DMTAC demonstrated consistent improvements in glycemic control and cardiovascular risk parameters. Conclusion: Clinical pharmacists enhance diabetes management through collaborative care, education, and therapy optimization, resulting in improved patient outcomes and reduced complications.