Bromelain is mix of proteolytic enzymes principally extract from fruit and stem the pineapple plant (Ananas comosus). It have lengthy historical past of standard medicinal use in various cultures, particularly in Central, South America, the place pineapple is native. Wound management continue to be critical aspect of healthcare driving the demand for effective, affordable sustainable. A wide range of therapeutic benefits have been claimed for bromelain including reversible inhibition of platelet aggregation, angina pectoris, bronchitis, sinusitis, surgical traumas, thrombophlebitis, enhanced absorption of Biochemical experiment indicate that these pharmacological properties depend of proteolytic activity only partly, suggesting the presence of nonprotein factors in bromelain pineapple peel an abundant agro-industrial waste contains valuable bioactive compounds bromelain, polyphenols, flavonoids with reported anti-inflammatory, antimicrobial and proteolytic properties useful in wound management. The review summarize phytochemical attribute of pineapple peel extract hydrogel patch material fabrication strategy Pineapple has main role in ethnopharmacology its enzyme bromelain has been extensive investigated for medicinal properties. Pineapple peel, major waste, Ananas comosus processing, is becoming promising natural resource for biomedical applications, especially for wound management. Rich in bioactive compounds like bromelain, flavonoids, phenolics and vitamin C, pineapple peel has significant antioxidant, anti-inflammatory and antimicrobial properties necessary for proper wound healing. This study aims to perform the effect of application of hydrogel patch containing pineapple peel extract..