Mouth ulcers often cause swelling, irritation, and a decrease in daily functioning of the oral mucosa. Growing dissatisfaction with the drawbacks of synthetic drugs has spurred interest in plant-based alternatives. This review highlights the therapeutic value of two medicinal plants that are frequently used in traditional healing systems: Glycyrrhiza glabra and Nyctanthes arbor-tristis. Their rich phytochemical composition, which includes flavonoids, glycosides, tannins, triterpenoids, and other phenolic compounds, supports a number of beneficial actions, such as anti-inflammatory, antioxidant, antibacterial, analgesic, and wound-healing properties. Research indicates that while N. arbor-tristis promotes tissue healing, reduces oxidative damage, and controls inflammatory pathways, G. glabra has important anti-ulcer, calming, antibacterial, and mucosal-protective qualities.