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ZENODO
Article . 2026
License: CC BY
Data sources: ZENODO
ZENODO
Article . 2026
License: CC BY
Data sources: Datacite
ZENODO
Article . 2026
License: CC BY
Data sources: Datacite
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Design And Development of Emulgel Containing Ibuprofen Using Central Composite Design

Authors: Dishari Dutta*, Annindya Pal, Paramita Dey;

Design And Development of Emulgel Containing Ibuprofen Using Central Composite Design

Abstract

Ibuprofen is chosen as the drug in the emulgel. Emulgel accommodates oil soluble drugs and enhances penetration of the drug. Ibuprofen (iso-butyl-phenyl-propionic acid) is a nonsteroidal anti-inflammatory drug (NSAID) that is used for treating pain, fever, and inflammation. Peceol oil is chosen in emulgel . Peceol oil is an oily vehicle used as a solubilizer for lipophilic APIs in oral and topical formulations. Ibuprofen emulgel is formulated by using Peceol Oil, Oleic Acid , Tween 20, Span 20, Liquid Paraffin, Carbopol940. Viscosity and Spreading Coefficient, pH, dilution test, centrifuge test, skin irritation, and analgesic activity are evaluated. The concentration of Peceol Oil and Oleic Acid is varied and the effect is seen in the parameters like viscosity and spreading coefficient using Design-Expert 13. Optimized Formulation shows good spreading coefficient and Viscosity. Analgesic activity showed similar results like marketed formulation.

Keywords

Emulgel,optimization, Peceol oil, oleic acid.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green