Background: Coronary artery disease (CAD) remains a leading cause of morbidity and mortality worldwide, with modifiable risk factors being prevalent among working professionals, particularly bank employees who lead sedentary lifestyles. Digital health interventions offer promising avenues for health promotion and disease prevention in workplace settings. Objective: To evaluate the effectiveness of a nurse-led digital wellness program on knowledge regarding the risk of coronary artery disease and its prevention among bank employees at selected banks in Jaipur, Rajasthan. Methods: A quasi-experimental research design was employed with 100 bank employees (50 in experimental group and 50 in control group) from State Bank of India branches in Jaipur. Non-probability purposive sampling was used. The experimental group received a nurse-led digital wellness program, while the control group received no intervention. Knowledge was assessed using a structured questionnaire (reliability r=0.772) before and after the intervention. Data were analyzed using descriptive and inferential statistics. Results: In the experimental group, pre-test mean knowledge score was 17.02 (SD=4.14), which significantly improved to 34.8 (SD=4.52) post-intervention (t=2.44, p0.05). In the experimental group, 74% participants achieved good knowledge levels post-intervention compared to 0% pre-intervention. Significant associations were found between post-test knowledge scores and dietary pattern, smoking habit, and alcoholic consumption (p<0.05). Conclusion: The nurse-led digital wellness program was highly effective in improving knowledge regarding coronary artery disease risk and prevention among bank employees. This intervention demonstrates the potential of technology-enabled nursing interventions for workplace health promotion.