This Teacher’s Guide has been developed within the framework of the EDIAQI Project (Evidence Driven Indoor Air Quality Improvement) to support the educational workbook designed for children aged 5 to 12 years old. Its main goal is to help educators integrate the topic of indoor air quality (IAQ) into classroom activities in an accessible, structured, and engaging way. The guide provides scientifically grounded explanations, key background information on indoor air pollutants (such as carbon dioxide, ozone, particulate matter, and volatile organic compounds), and their sources, effects on health, and links to environmental sustainability and public health. It also includes step-by-step instructions for conducting classroom activities, experiments, and interactive exercises featured in the student workbook. This material is designed to empower teachers to raise awareness and foster environmental responsibility from an early age, encouraging students to understand how everyday actions impact the air they breathe. The guide can be used in formal and non-formal education, including primary schools, environmental education programs, and outreach activities. By combining scientific content with hands-on learning, the Teacher’s Guide contributes to: Building environmental and health literacy among children. Supporting teachers in delivering impactful, evidence-based lessons. Encouraging active student participation and citizen awareness. Aligned with the goals of Horizon Europe and the EDIAQI project, this resource promotes sustainability, public health, and community engagement through education.