A key element of regulatory supervision is pharmaceutical inspections. They guarantee that pharmaceuticals are produced and supplied in compliance with accepted quality standards. By verifying adherence to Good Manufacturing Practices (GMP) and Good Distribution Practices (GDP), they primarily aim to safeguard the public's health. Inspections support the preservation of product safety, effectiveness, and uniformity throughout the pharmaceutical supply chain by conducting methodical assessments. Structured inspection programs are carried out by international regulatory bodies such as the World Health Organization (WHO), the Food and Drug Administration (FDA) in the United States, the European Medicines Agency (EMA), and the Central Drugs Standard Control Organization (CDSCO) in India. Pre-approval inspections, regular surveillance, and for-cause inspections are some of these programs. Prior to product authorisation, pre-approval inspections evaluate the facility's preparedness. Regular inspections keep an eye on continued compliance. Quality complaints, unfavourable incidents, or suspected infractions trigger for-cause inspections. When combined, these methods offer ongoing supervision over the course of the product's lifecycle. Pharmaceutical inspection systems are thoroughly examined in this chapter. Inspections of production sites, storage facilities, and distribution routes are highlighted. The national GMP inspectorates' quality management systems are highlighted. These systems address documentation practices, standardised procedures, inspector qualification, and training. There is also discussion of effective inspection reporting. Transparent communication of expectations and deficiencies is ensured and regulatory decision-making is supported by clear reports. The chapter delves deeper into international regulatory reliance and model GMP certification. These systems encourage mutual recognition between authorities and lessen inspection duplication. An essential tool for comprehending inspection results is root cause analysis. Instead of just fixing surface-level problems, it helps organisations to find underlying system failures. Strong Corrective and Preventive Action (CAPA) programs, which seek to address current issues and stop recurrence, are supported by this process. Globally, risk-based inspection techniques are becoming more and more popular. Facilities are ranked according to process complexity, compliance history, and patient risk. This enables regulators to concentrate resources on areas with the greatest impact. Global harmonisation efforts also align regulatory expectations and improve collaboration. In general, pharmaceutical inspections go beyond enforcing compliance. They serve as catalysts for organisational learning and quality improvement. Inspection systems improve supply chain resilience when they are backed by standardised, scientifically grounded frameworks. They also strengthen public trust. Most significantly, they guarantee the consistent delivery of safe and efficient medications to patients across the globe.