Nutritional security is a significant worldwide concern, particularly in underdeveloped countries where micronutrient deficits are common. Biofortification, or the practice of enhancing the micronutrient content of crops by conventional breeding, biotechnology, or agronomic techniques, has gained popularity as a long-term option for improving food nutrition. Horticultural crops, such as vegetables and fruits, are good biofortification vehicles due to their high vitamin, mineral, and phytonutrient content. This article investigates the significance of biofortified horticultural crops in increasing nutritional security, looks at breeding and biotechnological tactics, shows success stories, considers obstacles, and forecasts future opportunities. The integration of biofortification into mainstream horticulture production and nutrition policy has the potential to greatly enhance world health.