Abstract Quantum transport phenomena in nanoscale condensed matter systems represent a central area of modern solid-state physics, where charge, spin, and heat transport are governed by quantum coherence, confinement, and many-body interactions. At nanometer length scales, classical transport models fail to describe experimentally observed behaviors such as quantized conductance, tunneling, weak localization, Coulomb blockade, and topologically protected edge transport. This paper examines the theoretical foundations and experimental realizations of quantum transport in low-dimensional systems, including quantum dots, nanowires, two-dimensional materials, and topological materials. Using a mixed theoretical–experimental synthesis approach, recent developments up to mid-2025 are analyzed to illustrate how quantum coherence, disorder, electron–electron interactions, and topology collectively shape transport properties. The study further discusses advances in nanoscale fabrication and measurement techniques that have enabled precise control of quantum transport, as well as implications for nanoelectronics, spintronics, and quantum technologies.