
Colon cancer is the third most commonly diagnosed malignancy and the second leading cause of cancer-related mortality; therefore, timely and accurate diagnosis is essential. Histopathology is the gold standard, but it can be slow and variable. We present a lightweight deep learning (DL) model for binary classification of colon histopathology images that emphasises robustness and computational efficiency. Using DenseNet169 with transfer learning (TL) on 10,000 images (5,000 cancerous; 5,000 normal), we applied extensive on-the-fly augmentation and a 2-phase training strategy without stain normalization. The model achieved strong validation performance with an accuracy 0.9942, precision 0.9917, recall 0.9967, F1-score 0.9942, and AUC 0.9998, with ROC analysis indicating near-perfect separation. We utilised a three-fold cross-validation which showed consistent performance across folds, supporting generalization. Compared with stain-normalized ResNet-50 baselines, our approach remains competitive while reducing preprocessing burden, improving practicality for resource-constrained environments. These results underscore the potential of optimised TL with DenseNet169 to deliver fast, reliable decision support in pathology without complex preprocessing.
colon cancer, deep learning, histopathology images, transfer learning
colon cancer, deep learning, histopathology images, transfer learning
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