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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao ZENODOarrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
ZENODO
Article . 2026
License: CC BY
Data sources: ZENODO
ZENODO
Article . 2026
License: CC BY
Data sources: Datacite
ZENODO
Article . 2026
License: CC BY
Data sources: Datacite
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Application of a Deep-Learning Architecture in Colon Cancer Prediction Using Histopathology Images

Authors: Sotonwa, Kehinde Adebola; Ogunyemi, Oluwapelumi Oluwatosin; Olowo, Tomiloba Israel; Aliyu, Mariam;

Application of a Deep-Learning Architecture in Colon Cancer Prediction Using Histopathology Images

Abstract

Colon cancer is the third most commonly diagnosed malignancy and the second leading cause of cancer-related mortality; therefore, timely and accurate diagnosis is essential. Histopathology is the gold standard, but it can be slow and variable. We present a lightweight deep learning (DL) model for binary classification of colon histopathology images that emphasises robustness and computational efficiency. Using DenseNet169 with transfer learning (TL) on 10,000 images (5,000 cancerous; 5,000 normal), we applied extensive on-the-fly augmentation and a 2-phase training strategy without stain normalization. The model achieved strong validation performance with an accuracy 0.9942, precision 0.9917, recall 0.9967, F1-score 0.9942, and AUC 0.9998, with ROC analysis indicating near-perfect separation. We utilised a three-fold cross-validation which showed consistent performance across folds, supporting generalization. Compared with stain-normalized ResNet-50 baselines, our approach remains competitive while reducing preprocessing burden, improving practicality for resource-constrained environments. These results underscore the potential of optimised TL with DenseNet169 to deliver fast, reliable decision support in pathology without complex preprocessing.

Keywords

colon cancer, deep learning, histopathology images, transfer learning

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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Cancer Research
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