The realization of scalable, fault-tolerant quantum computing is currently impeded by the rapid decoherence of standard silicon spin qubits and the materials engineering challenges associated with intrinsic topological superconductors. We present a novel heterostructure design combining pre-synthesized Wurtzite-phase GaP/SiGe core-shell nanowires with Iridium Oxide (Ir02), where Floquet engineering manipulates electronic topology rather than crystal structure. This approach leverages established semiconductor manufacturing techniques while targeting the noise-immunity of topological phases. Our preliminary tight-binding simulations confirm the emergence of protected edge states at the interface, while Monte Carlo simulations of a Distance-3 Surface Code yield error suppression consistent with a threshold of approximately 0.9% under a phenomenological Pauli noise model. We outline a critical path for experimental realization including ab initio DFT verification of interface stability and hexagonal boron nitride encapsulation for strain mitigation.