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Article . 2025
License: CC BY
Data sources: Datacite
ZENODO
Article . 2025
License: CC BY
Data sources: Datacite
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Antibacterial Properties of House Fly (Musca domestica) Wings: Physico-Chemical Mechanisms and Identification of Antimicrobial Peptides

Authors: Coskun, Teoman; Dupont, Lucas; Moreau, Sarah; Lefèvre, Thomas; Bertrand, Emma;

Antibacterial Properties of House Fly (Musca domestica) Wings: Physico-Chemical Mechanisms and Identification of Antimicrobial Peptides

Abstract

Cette étude examine les propriétés antibactériennes des ailes de la mouche domestique (Musca domestica) par le biais d'expériences contrôlées, d'analyses microscopiques et d'une caractérisation moléculaire. Les résultats révèlent un double mécanisme d'action : un effet mécanique dû à des nanopiliers (307 ± 45 nm) présents à la surface de l'aile, et un effet chimique via des peptides antimicrobiens. L'activité antibactérienne a été quantifiée par des zones d'inhibition de 8,9 à 14,1 mm, une inhibition de la croissance de 42 à 57 % et une mortalité cellulaire de 50 à 74 %. L'analyse MALDI-TOF a permis d'identifier des peptides antimicrobiens clés, notamment les cécropines (3847 Da) et les défensines (4123 Da). Ces travaux soulignent le potentiel des surfaces alaires d'insectes comme source de nouveaux agents antibactériens et apportent un éclairage nouveau sur leurs mécanismes physico-chimiques.

Keywords

Musca domestica, house fly, antimicrobial peptides, cecropins, defensins, nano-topography, wing microstructure, physico-chemical mechanisms, antibacterial activity, MALDI-TOF, insect-derived biomolecules, nanostructured surfaces, bioinspired antibacterial materials, surface-mediated bacterial inhibition, mechanotransduction, membrane disruption, biomimetic antimicrobial surface design, functional peptides, structure–function relationship, cytotoxicity, peptide characterization

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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