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Other literature type . 2026
License: CC BY
Data sources: Datacite
ZENODO
Other literature type . 2026
License: CC BY
Data sources: Datacite
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Stabilization of Amorphous Biologics via Geometric Frustration in Mesoporous Silica: Mechanistic Insights for Rescuing Pharmacokinetically Flawed Therapeutics

Authors: Tunnicliffe, Ross;

Stabilization of Amorphous Biologics via Geometric Frustration in Mesoporous Silica: Mechanistic Insights for Rescuing Pharmacokinetically Flawed Therapeutics

Abstract

This paper details a stimuli-responsive 'Vimana' architecture designed to stabilize fragile biologics through nanoconfinement-induced geometric frustration. By integrating a phyllosilicate thermal mantle with a piezoelectric cyclosilicate resonator, we demonstrate a solid-state vehicle capable of maintaining amorphous stability under high-heat stress (>50°C) and achieving magneto-acoustic triggered release. This mineral-based platform provides a hierarchical mechanical intervention to rescue 'Lazarus' compounds—therapeutics with high biological efficacy but prohibitive pharmacokinetic flaws.

Keywords

SBA-15, Drug Delivery Systems, Mesoporous Silica, Piezoelectrics, Piezoelectric Transduction, Pharmacokinetics, Silicon Dioxide

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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