Mandibular incisal crowding is described as the discrepancy between the mesiodistal widths of the four permanent incisors andthe available space in the alveolar process. The aim of this research is to assess the potential influence of mandibular thirdmolars on the development of lower incisor crowding and to analyze the relationship between mandibular incisal crowding andretromolar eruption space, eruption level and angulation of third molars. For the realization of our objectives examinations areperformed on study plaster orthodontic models (mandibular dental arches) and orthopantomographic images of 80 individuals,aged between 12 and 22 years. The whole sample is divided into two groups based on the Little’s index of irregularity: group Icontrol group composed of patients with index 0 to 3 mm, and group II- study group composed of patients with index >3 mm.Calculations are made for the third molar eruption depth, eruption space, and angulation. The influence of the third molar onmandibular incisor crowding is evaluated in the dental literature and has been a challenging subject for many years. Furtherdetailed studies are also required to assess correlation between lower anterior crowding and third molar eruption depth,angulation and space in different skeletal malocclusions, and also in different facial morphologies.