Background: Asthimajjagatvata Described in Ayurveda Resembles Ankylosing spondylitis, a systemic Inflammatory Auto immune Disease With chronic lower back pain Alternative buttock Pain Due to sacroiliac joint inflammation and progressive spinal rigidity. Objective: To evaluate ayurvedic management in case of Asthimajjagatvata (ankylosing spondylitis Method: A 31year-old female with restricted movement of the shoulder joint and hip joint, morning stiffness lasting more than 30 minutes, and neck stiffness was treated with Simhanad Guggulu, Punarnava Guggulu, Aamvatari Ras, along with Panchakarma therapies including Vaitaran Basti and Valuka Pottali Sweda. Result: within 15 days of treatment marked improvement was observed in morning stiffness and restricted movement and reduces patient discomfort. Conclusion: Ayurvedic medicines in conjunction with Panchakarma therapy are effective in alleviating symptoms of Ankylosing Spondylitis. The intervention appears to reduce vitiated Vata and Kapha doshas, restore disturbed joint movements, and enhance overall quality of life by nourishing the body and supporting functional improvement.