This study presents an integrated medical model explaining Henry VIII's reproductive failures and progressive physical decline through six interacting factors: Kell antigen incompatibility, lead poisoning, chronic psychological stress, exercise deprivation, traumatic brain injury, and congestive heart failure. Statistical analysis of pregnancy outcomes across three wives demonstrates that the observed pattern of reproductive loss is 6.5 times more likely under a Kell-positive father model than by random chance alone. The analysis challenges traditional narratives attributing Henry's decline to moral failings, instead positioning his transformation as the physiological consequence of cumulative medical catastrophes. This work contributes to medical biography by applying modern clinical frameworks to historical cases and demonstrates how biological factors amplified dynastic crises leading to major historical events including the English Reformation.