In this talk, I will discuss the TYPHOON survey, the largest nearby sample of galaxies with 3D data cubes which will be used as a benchmark to calibrate and quantify the impact of variable stellar chemical abundances on emission lines. We will talk about enrichment at the scales of individual HII regions and how supernova yields inform on global mixing scales across entire galaxies. The work presented here represents a first step necessary in order begin providing clear constraints for galaxy evolution theory by combining observations and state-of-the-art modelling as the theoretical basis to derive new, robust galaxy diagnostics across cosmic time.