Odontogenic phlegmon represents a severe purulent-inflammatory condition of maxillofacial soft tissues arising from dental and periodontal infections. In adolescents, this pathology demonstrates particular clinical importance due to anatomical, physiological, and behavioral characteristics that predispose this age group to rapid disease progression and complications. The present article aims to analyze the etiological factors, pathogenetic mechanisms, age-related characteristics, and medical-social determinants of odontogenic phlegmon development among adolescents in the Fergana region based on a synthesis of clinical data, scientific literature, and theoretical evidence. Special attention is given to the classification of phlegmon, its origin, and the distinctive patterns of formation across different age groups. The article further explores why odontogenic phlegmon occurs frequently in children and adolescents, emphasizing the role of untreated dental caries, poor oral hygiene, delayed access to dental care, socioeconomic barriers, and insufficient preventive programs. Available statistical trends from regional and international studies are incorporated to demonstrate prevalence patterns and risk distribution. The findings highlight that odontogenic phlegmon in adolescents is not only a clinical problem but also a public health issue requiring integrated preventive strategies. Strengthening school-based oral health education, improving accessibility of dental services, and implementing early diagnostic protocols are essential for reducing disease burden. The article concludes with evidence-based recommendations aimed at enhancing preventive and therapeutic approaches within pediatric and adolescent dentistry.