Abstract - This document presents an original, rule-guided methodology for translating genetic sequence information into constrained musical structures through biologically informed reduction and symbolic mapping. Unlike arbitrary or purely aesthetic DNA-to-sound mappings, the proposed framework employs biologically motivated sequence reduction, symbolic abstraction using dinucleotide units, and constraint-based musical mapping. The method emphasizes information density, avoidance of genomic redundancy, and preservation of an explicit human interpretive layer. The resulting musical output is not intended as a literal transcription, but as a constrained, interpretable musical representation grounded in genomic structure. This methodology is designed for artistic, exploratory, and conceptual use, rather than diagnostic or clinical interpretation.