The lack of control of the occurrence of harmonic distortion results to the power system equipment overheating thereby increasing in energy loss, premature aging of the equipment, inaccuracy and reliability issues in sensitive and critical electronic devices. The harmonic distortions are majorly caused by non-linear loads and injection of renewable energy devices mainly, solar system network which are necessary for day-to-day activities. Hence, the paper utilized a standalone single-tuned passive filter and a hybrid of a passive filter and ANN model control mechanism for the mitigation of the impact of harmonic distortion on the Nigerian 330kV transmission network situated in the North central region of the country. The total harmonic distortion (THD) metrics were utilized for the determination of the performance of the filters utilized sequentially in mitigating the impact of the harmonic’s distortion on the current and voltage signals. From the outcome of the simulation, the utilization of the hybrid filter had the best performance as it reduced the THD of the current signal to 1.072% and 1.213% for the Benin kebbi and Kainji bus stations respectively and voltage signal to 1.772% and 1.993% for the Benin kebbi and Kainji bus stations respectively.