This research examined the association between mental health, resilience and Work-life Balance of employees working across different public and private sectors and whether mental health and Resilience are competent predictors of Work-life Balance (WLB). For data compilation, Mental Health Inventory by Jagdish and Srivastav (1995), Brief Resilience Scale (2008), and Hayman's Work-life Balance Scale (2005) were used. The study was conducted on a total of 250 employees working in both public and private sectors. To examine the data, correlational and regression analyses were conducted. Correlational analysis revealed that mental health, resilience and work-life balance are positively correlated with each other. Further findings of the study reveal that mental health and resilience are significant predictors of work-life balance. Research also concludes that public sector when compared with private sector has better performance in the light of the above-mentioned variables. These outcomes have essential theoretical implications related to the relations between individual and organization. In addition, the findings of this study can be implemented to develop empirically supported intervention programs and support services to employees in achieving a better WLB.