This whitepaper presents a 2026-ready, production-grade reference architecture for Autonomous Orchestration in Enterprise Supply Chains. Modern logistics systems suffer from decision latency—the widening gap between real-time operational signals and validated decisions. This architecture eliminates that gap by integrating a Tri-Engine AI Decision System: 1. Probabilistic Forecasting EngineGenerates uncertainty-aware predictions (P10/P50/P90) that capture volatility across demand, lead time, and supply signals. 2. Constraint-Aware Optimization EngineUses Mixed-Integer Linear Programming, OR-Tools, and bounded RL to produce resilient, feasible operational plans validated through digital twin simulations. 3. Agentic Decision Intelligence EngineProduces structured, policy-grounded Decision Briefs using RAG-based LLM reasoning, in accordance with strict safety and compliance rules. The system is supported by enterprise-grade governance, security, human-in-the-loop oversight, and explainable AI frameworks, ensuring every autonomous action is transparent, auditable, and policy-aligned. Temporal, LangGraph, MLflow, OPA, Kafka, and Delta Lake form the backbone of the architecture, enabling durable workflows, multi-agent orchestration, lineage tracking, and high-throughput data ingestion. This whitepaper is accompanied by a full technical walkthrough video titled:“AI Supply Chain Architecture 2026 — Forecast. Optimize. Decide. Autonomously.” “Together, the video and whitepaper form a complete reference for implementing autonomous, self-healing supply chain intelligence at enterprise scale.”