Note on scope and intent This work is presented as a conceptual and mechanistic framework intended to guide future experimental and translational studies. The models, integration strategies, and proposed combinations described here reflect how we currently understand and approach the problem space, rather than a claim of completed validation. Specific implementations, datasets, and experimental confirmations are expected to evolve as the framework is tested, refined, and extended through ongoing and future work.

We performed an in silico systems-level functional association and enrichment analysis using the STRING database to assess whether a curated FG-001 Triplet axis gene/protein set forms a coherent non-random antiviral immune network. The analysis demonstrates highly signifi- cant protein–protein interaction enrichment and strong overrepresentation of antiviral response, interferon-associated innate immunity, and chemokine-mediated trafficking programs.