Portugal’s healthcare and scientific ecosystem is poised to strengthen its position as a regional leader in clinical and translational research. The GIMM CARE initiative proposes a scalable, multi‑centric operating model that connects hospitals, universities, and industry partners to foster innovation, accelerate clinical trials, and improve patient access to cutting‑edge therapies. This policy brief outlines the strategic context, operational framework and implementation roadmap necessary to establish GIMM CARE Clinical Research Hub as a national and international reference model for clinical research management.