This Zenodo record is a permanently preserved version of a Structured PREreview. You can view the complete PREreview at https://prereview.org/reviews/18345188. Does the introduction explain the objective of the research presented in the preprint? Yes Are the methods well-suited for this research? Highly appropriate Are the conclusions supported by the data? Somewhat supported The measurement of social isolation and marijuana use (medical/recreational) needs to be more robust as there are three categories of Marijuana use- Medical, medical/recreational, and recreational. Social isolation if correlated with the two extremes of the spectrum from medical to recreational would help understand which category the majority lies in. Whereas the "medical/recreational" category would benefit from an added confounding factor to determine significance of inclination towards either side of the spectrum. Are the data presentations, including visualizations, well-suited to represent the data? Highly appropriate and clear How clearly do the authors discuss, explain, and interpret their findings and potential next steps for the research? Very clearly Is the preprint likely to advance academic knowledge? Somewhat likely Would it benefit from language editing? No Would you recommend this preprint to others? Yes, but it needs to be improved Is it ready for attention from an editor, publisher or broader audience? Yes, after minor changes Competing interests The author declares that they have no competing interests. Use of Artificial Intelligence (AI) The author declares that they did not use generative AI to come up with new ideas for their review.