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ZENODO
Other literature type . 2026
License: CC BY
Data sources: ZENODO
ZENODO
Other literature type . 2026
License: CC BY
Data sources: Datacite
ZENODO
Other literature type . 2026
License: CC BY
Data sources: Datacite
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FORMULATION DEVELOPMENT AND EVALUATION OF IMMEDIATE RELEASE TABLET DOSAGE FORM OF AMANTADINE

Authors: Nomula Veenasri* , M. Mounika, Dr. Alivelu Samala;

FORMULATION DEVELOPMENT AND EVALUATION OF IMMEDIATE RELEASE TABLET DOSAGE FORM OF AMANTADINE

Abstract

The objective of this study was to develop and evaluate an immediate-release (IR) tablet dosage form of amantadine, an antiviral drug primarily used in the treatment of influenza and Parkinson's disease. Amantadine is known for its rapid absorption and onset of action, making it suitable for an IR formulation. Various excipients were selected based on their ability to enhance drug solubility and bioavailability. The tablets were prepared using direct compression and evaluated for physical characteristics, including hardness, friability, weight variation, and disintegration time. In vitro dissolution studies were conducted to assess the release profile of amantadine, ensuring it met the required pharmacokinetic parameters for rapid onset. The results indicated that the formulation provided efficient and rapid drug release, with acceptable pharmacotechnical properties. Keywords: Amantadine, Croscarmellose sodium, Sodium starch Glycolate and Crospovidone

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average