
The objective of this study was to develop and evaluate an immediate-release (IR) tablet dosage form of amantadine, an antiviral drug primarily used in the treatment of influenza and Parkinson's disease. Amantadine is known for its rapid absorption and onset of action, making it suitable for an IR formulation. Various excipients were selected based on their ability to enhance drug solubility and bioavailability. The tablets were prepared using direct compression and evaluated for physical characteristics, including hardness, friability, weight variation, and disintegration time. In vitro dissolution studies were conducted to assess the release profile of amantadine, ensuring it met the required pharmacokinetic parameters for rapid onset. The results indicated that the formulation provided efficient and rapid drug release, with acceptable pharmacotechnical properties. Keywords: Amantadine, Croscarmellose sodium, Sodium starch Glycolate and Crospovidone
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