The article focuses on examining how digitalization influences the localization of production processes and the growth of industrial cooperation in Uzbekistan. In the context of accelerated digital transformation of the global economy, digitalization is becoming a key tool for increasing technological independence, production efficiency, and integration into global value chains. Based on statistical data from international organizations (World Bank, UN Comtrade, WIPO, ADB), it is shown that between 2015 and 2023, Uzbekistan experienced a growth in the share of medium- and high-tech industries, an increase in high-tech product exports, and an expansion of digital infrastructure. The implementation of the "Digital Uzbekistan—2030" state strategy contributes to the formation of national digital ecosystems, the development of technology parks, and the introduction of ERP systems, IoT, and AI solutions in industry. It is concluded that digitalization is one of the factors in strengthening Uzbekistan's technological sovereignty and transitioning to an innovative economic growth model based on the synergy of digital technologies, localization, and industrial cooperation..