Background: The quality of work of health workers is an important determinant in patient safety, service effectiveness, and hospital performance. At Konawe Hospital, the increasing service load and task complexity require strong organizational support and a reward system that is able to encourage optimal performance. Objective: This study aims to analyze the influence of organizational support on the quality of work of health workers and examine the role of reward as a mediating variable in the relationship. Methods: The study used a quantitative design with a cross-sectional approach. A total of 170 health workers were selected through proportionate stratified random sampling. Data were collected using standardized instruments and analyzed with Partial Least Squares–Structural Equation Modeling (PLS-SEM) version 4.0. Model evaluation was carried out through tests of validity, reliability, path coefficient, mediation effect, and predictive relevance (Q²predict, RMSE, MAE). Results: Organizational support had a positive and significant effect on awards (β = 0.660; t = 14.574; r = 0.000). Awards also had a significant effect on the quality of work (β = 0.470; t = 7.066; r = 0.001). The mediation test showed that the award was a significant mediator in the relationship between organizational support and work quality (β = 0.310; t = 5.871; r = 0.000). The Q²predict value of 0.417 for the award and 0.223 for the quality of work indicates the model's adequate predictive capabilities. Conclusion: Organizational support has been shown to improve the quality of work of health workers, both directly and through the mediation of awards. Awards serve as an important mechanism that amplifies the impact of an organization's support on performance improvement. The implementation of a fair and structured award system needs to be integrated with a strategy to strengthen organizational support to improve the quality of services in regional hospitals.