This work introduces a minimal quantitative response-theory model extending the phenomenological framework of ZIP cosmology toward direct experimental testability. Rather than postulating a microscopic description of the informational configuration of spacetime, the model focuses on the measurable response of a physical system to a structured, coherent external perturbation. The framework treats any potential ZIP-related effect as a non-standard response kernel that vanishes under symmetric or incoherent perturbations and may become non-zero only in the presence of controlled spatial and temporal asymmetry. Importantly, the response is predicted to depend on structural and phase properties of the perturbation rather than on its total energy or power, ensuring consistency with conservation laws. The proposed formalism allows experimental data to place quantitative upper bounds on ZIP-related effects or, in the event of a reproducible non-zero response, to signal the presence of non-standard physics. By framing ZIP cosmology in the language of response theory, this work establishes a clear empirical boundary between standard physics and potential informational reconfiguration effects, without invoking speculative energy extraction mechanisms.