Standard quantum mechanical interpretations rely on wave-particle duality to explain energy transduction, yet this duality often obscures the distinct functional roles of force carriers and matter particles in driven non-equilibrium systems. This manuscript proposes a radical “Signal-Worker” ontology where bosons (photons/phonons) act strictly as informational signals directing localized fermions (electrons/excitons) to perform work. By synthesizing evidence from phonon-assisted photosynthesis and light-induced superconductivity, we identify a fundamental structural isomorphism in how ambient temperature coherence is engineered. We demonstrate that biological systems utilize constructive thermal noise—specifically environment-assisted quantum transport (ENAQT)—as a bosonic signal, a principle that maps directly to Floquet engineering in condensed matter physics. Formalizing this via a unified Signal-Worker Hamiltonian ($H_{SW}$) reveals that the stability of photosynthetic excitons and the transience of light-induced Cooper pairs are distinct regimes of the same governing dynamic. We present design rules for transferring biological protein-scaffold stability into crystal lattice engineering, offering a non-dualistic pathway to designing robust room-temperature quantum technologies.