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Preprint . 2026
License: CC BY
Data sources: Datacite
ZENODO
Preprint . 2026
License: CC BY
Data sources: Datacite
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Translating System Dynamics into Clinical Strategy Conceptually informed by the Universal Resonance Model (URM)

Authors: Domargård, Anita;

Translating System Dynamics into Clinical Strategy Conceptually informed by the Universal Resonance Model (URM)

Abstract

This paper explores how concepts from systems dynamics and the Universal Resonance Model (URM) can be translated into practical clinical reasoning. Rather than treating disease as a static state defined by thresholds and categories, it interprets illness as a dynamic process shaped by instability, recovery, and adaptive capacity. The text shows how features such as variability, recovery speed, timing sensitivity, and proximity to transition can inform therapeutic strategy—guiding when to intervene, how strongly to perturb a system, and why the same treatment may succeed in one patient and fail in another. It does not propose new clinical protocols, but offers an interpretive layer that helps clinicians understand treatment response, resistance, and delayed effects in complex diseases. By shifting focus from static biomarkers to system behavior, the paper provides a conceptual bridge between precision medicine and dynamic medicine, supporting more context-sensitive and timing-aware clinical decision-making.

Keywords

clinical decision-making, translational concepts in medicine, systems dynamics, precision medicine, precision and personalized medicine, adaptive systems, Universal Resonance Model, theoretical medicine, disease trajectories, treatment resistance, instability, recovery, Dynamic medicine, system behavior, Systems medicine, disease modeling, treatment strategy design, clinical reasoning, treatment timing, therapeutic strategy, resilience, resilience and recovery in health, complex adaptive systems

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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