AbstractBackground: Statin use is widespread. Statins+/-ezetimibe is thought to promote improvement in alopecia areata,an autoimmune disease characterized by round patches of non-scarring hair loss.Objective: To elucidate the relationship between statins and alopecia areata improvement.Methods: Retrospective cohort study of 6617 patients with hair disorders who visited a large metropolitanhealthcare system between June 2013 to May 2017. The primary outcome was an improvement in alopecia areataafter exposure to statins using statistical analyses (relative risk, logistic regression).Results: Best predictors of AA include age and whether patients received intralesional triamcinolone acetonideinjections. Statins are not an independent predictor of AA improvement. Age is a confounding factor for evaluatingthe use of statins on improvement of AA.Limitations: Since this study involves retrospective chart review, the design has limited ability to determinecausality, though this was mitigated by statistical methods.Conclusions: Our data do not support statins as an effective therapy for alopecia areata.