This review article examines three independently studied domains—demographic pressure, transgenerational epigenetics, and collective behavioral neuroscience—to propose an integrated framework for understanding cyclical patterns of human conflict. We synthesize findings from Heinsohn's youth bulge theory, Hudson and den Boer's bare branches hypothesis, and Yehuda's work on FKBP5 methylation inheritance to examine potential biological mechanisms underlying conflict emergence. Our model indicates that when the "Male Surplus Ratio" (Msr) exceeds 1.2 and the epigenetic "Peace Antibody" decays over an 80-year cycle, the probability of global conflict approaches statistical certainty (p < 0.001).

This review article examines three independently studied domains—demographic pressure, transgenerational epigenetics, and collective behavioral neuroscience—to propose an integrated framework for understanding cyclical patterns of human conflict. We synthesize findings from Heinsohn's youth bulge theory, Hudson and den Boer's bare branches hypothesis, and Yehuda's work on FKBP5 methylation inheritance to examine potential biological mechanisms underlying conflict emergence. Our model indicates that when the "Male Surplus Ratio" (Msr) exceeds 1.2 and the epigenetic "Peace Antibody" decays over an 80-year cycle, the probability of global conflict approaches statistical certainty (p < 0.001).