This original prospective study evaluated the efficacy of adding rectal suppositories containing streptokinase (15,000 IU) and streptodornase (1,250 IU) to standard postoperative treatment following surgical intervention for anal fissures. Conducted from July 2014 to July 2017, the research involved 220 patients divided into two groups of 110 each. The control group received standard care according to international guidelines, while the study group received the same plus the suppositories. Application regimens varied by disease severity: for severe cases, one suppository three times daily for the first three days, twice daily for the next three, and once daily for the following three; for moderate to mild cases, twice daily for three days followed by once daily for four days or twice daily for two days. Outcomes demonstrated superior results in the study group, including reduced hospital stay (5.4 ± 1.8 days vs. 7.2 ± 2.1 days, p < 0.01), fewer severe disease courses (10% vs. 25%, p < 0.05), lower complication rates (5% vs. 15%, p < 0.05), diminished pain intensity via Visual Analog Scale (VAS), and higher treatment satisfaction on a 100-point scale. Statistical analysis using IBM SPSS Statistics version 20 confirmed significant differences. These findings suggest that incorporating streptokinase-streptodornase suppositories optimizes postoperative recovery, potentially improving patient outcomes in anal fissure management.