This study investigates the effect of human consciousness on the molecular structure of water using a double-blind, randomized controlled design. Ultra-purified water samples were exposed to positive emotional intention, negative intention, sham interaction, or no contact. FTIR spectroscopy revealed a 6 cm⁻¹ shift in OH-stretching and a +0.015 increase in absorbance in the positive intention group (p = 0.013). NMR showed a downfield shift from δ = 4.78 ppm to 4.82 ppm (p = 0.018), and DLS indicated a 14% increase in cluster size (p = 0.009). Crystallization analysis found 63% of positive intention samples formed symmetrical crystals versus 45% in controls (p < 0.01). These results suggest that focused human intention may induce subtle, measurable structural changes in water, warranting further study into consciousness-based interactions.